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DSECT/DSEN Monthly Seminar Series - Mar 24, 2016

“A Multi-Center Observational Study of Incretin-Based Drugs and Heart Failure”

Presented by
Kristian B. Filion, PhD

Assistant Professor of Medicine, Division of Clinical Epidemiology, McGill University
Principal Investigator, Centre for Clinical Epidemiology, Lady Davis Institute, Jewish General Hospital

Thursday, March 24th at 3-4pm EDT

Online via GoToWebinar

Click here to access the webinar recording


Incretin-based drugs, which include GLP-1 analogs and DPP-4 inhibitors, are commonly used for the treatment of type 2 diabetes. Safety concerns have emerged surrounding their use, including conflicting evidence regarding a possible association with heart failure. This issue was examined by the Canadian Network for Observational Drug Effect Studies (CNODES). This presentation will describe this CNODES study, which involved the use of a common-protocol approach using healthcare data for over 1.4 million individuals from six jurisdictions across three countries (Canada, the United States, and the United Kingdom) to examine the association between incretin-based drugs and the risk of heart failure.

Learning Objectives:

  1. To understand the role of CNODES in the post-marketing assessment of adverse drug reactions in Canada.
  2. To understand the potential association between incretin-based drugs and the risk of heart failure.


Filion KB, Azoulay L, Platt RW, et al. A Multicenter Observational Study of Incretin-based Drugs and Heart Failure. N Engl J Med 2016; 374:1145-1154.
DOI: 10.1056/NEJMoa1506115  


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