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DSECT/DSEN Monthly Seminar Series - Feb 23, 2017

“Drug Hypersensitivity: Mechanistic and clinical implications for prediction and diagnosis”

Presented by

Baset A Elzagallaai, BSc Pharm, MSc, PhD
Postdoctoral Associate, Department of Paediatrics, Schulich School of Medicine and Dentistry and Robarts Research Institute, Western University

Thursday, February 23rd at 3-4pm EST

Online via GoToWebinar

Click here to access the webinar recording


Download Event Flyer (PDF)



Drug hypersensitivity reactions (DHRs) are adverse drug reactions (ADRs) that belong to type B ADRs (idiosyncratic reactions). While individually uncommon, collectively they are among the most serious ADRs seen clinically. Prediction and diagnosis of DHRs are difficult because of their varied clinical presentation and lack of understanding of the underlying pathophysiology. However, a body of evidence exists that support the involvement of the immune system in the majority of DHRs. This webinar will give an overview of the current understanding of the pathophysiology of DHRs and methods used for prediction and diagnosis.

Learning Objectives:

  1. To explore the current statistics and epidemiology of DHRs.
  2. To give a brief overview of different hypotheses explaining the pathophysiology of DHRs.
  3. To give a brief account of the advantages and pitfalls of in vivo and in vitro diagnostic tests for DHRs.


  • Elzagallaai AA, Rieder MJ. In vitro testing for diagnosis of idiosyncratic adverse drug reactions: Implications for pathophysiology. Br J Clin Pharmacol. 2015 Oct;80(4):889-900.
  • Uetrecht J, Naisbitt DJ. Idiosyncratic adverse drug reactions: current concepts. Pharmacol Rev. 2013 Mar 8;65(2):779-808.