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DSECT/DSEN Monthly Seminar Series - Jan 25, 2018


“The influence of early cumulative drug exposure on the risk of joint replacement surgeries in rheumatoid arthritis”


Presented by

Cristiano S. Moura, PhD
Research Associate, Centre for Outcomes Research and Evaluation, McGill University


Thursday, January 25, 2018    3-4pm EST

Online via GoToWebinar

Webinar Recording (MP4)




Treatment strategies for RA have improved dramatically over the past decade. RA patients undergoing early intensive treatment may obtain superior clinical responses than if the same care is administered later in the disease course. Early drug exposure soon after RA diagnosis reduces the risk of subsequent joint replacement surgery. To assess this issue, we studied the potential association between RA drug use and joint replacement using a population-based RA cohort assembled from health administrative databases in Quebec.

Learning Objectives:

  1. To review considerations when modeling drug exposure in comparative effectiveness research.
  2. To discuss the influence of cumulative early treatment on joint replacement surgeries in RA patients.


  • Moura CS, Abrahamowicz M, Beauchamp ME, Lacaille D, Wang Y et al. Early medication use in new-onset rheumatoid arthritis may delay joint replacement: results of a large population-based study. Arthritis Res Ther. 17:197, 2015.

  • Dixon WG, Abrahamowicz M, Beauchamp ME et al. Immediate and delayed impact of oral glucocorticoid therapy on risk of serious infection in older patients with rheumatoid arthritis: a nested case-control analysis. Ann Rheum Dis 2012;71(7):1128-1133.