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DSECT/DSEN Monthly Seminar Series - Feb 22, 2018


“Exploring the relevance of frailty measures to medication use and outcomes in older adults”


Presented by

Colleen J Maxwell PhD
Professor and University Research Chair
Schools of Pharmacy and Public Health & Health Systems
University of Waterloo
Adjunct Scientist, Institute for Clinical Evaluative Sciences
Adjunct Professor, Community Health Sciences, University of Calgary


Thursday, February 22, 2018    3-4pm EST

Online via GoToWebinar





This presentation will provide a brief summary of frailty assessment approaches relevant to pharmacoepidemiologic research and present findings from current research on the importance of frailty as an effect modifier of drug-related outcomes in older populations. Findings from observational studies utilizing linked clinical and administrative health databases will be highlighted. Implications for future research and clinical and health policy initiatives will also be summarized.

Learning Objectives:

  1. Promote awareness and understanding of the most common approaches to defining frailty in pharmacoepidemiologic data, including relevant strengths and limitations of measures.
  2. Increase understanding of current research (and knowledge gaps) on potential bi-directional associations between frailty and drugs (and drug related outcomes).
  3. Facilitate further research on the importance of frailty measures when examining and defining the relative benefits and risks of drugs in older populations.


  • Maxwell CJ, Campitelli MA, Hogan DB, Diong C, Austin PC, Amuah JE, Lapane K, Seitz DP, Gill SS, Gruneir A, Wodchis WP, Bronskill SE. Relevance of frailty to mortality associated with the use of antipsychotics among community-residing older adults with impaired cognition. Pharmacoepidemiol Drug Saf. 2018 Jan 10. Doi: 10.1002/pds.4385 [Epub ahead of print].

  • Maclagan LC, Maxwell CJ, Gandhi S, Guan J, Bell C, Hogan D, Daneman N, Gill S, Morris A, Jeffs L, Campitelli M, Seitz D, Bronskill SE. Frailty and potentially inappropriate medication use at nursing home transition. J Am Geriatr Soc 2017;65(10):2205-2212.

  • Stock KJ, Hogan DB, Lapane K, Amuah JE, Tyas SL, Bronskill SE, Morris AM, Bell CM, Jeffs L, Maxwell CJ. Antipsychotic use and hospitalization among older assisted living residents: Does risk vary by frailty status? Am J Ger Psych 2017;25(7):779-90.